Asymmetric transformations in salts of phenylmalonamic and phenylmalonanilic acids. The kinetics of racemisation of phenylmalonamic acid
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 9,p. 1204-1207
- https://doi.org/10.1039/p29730001204
Abstract
Phenylmalonamic acid may be obtained in active form by treatment with (–)-cinchonidine- in ethanol, chloroform, or acetone, the latter solvent yielding acid with the highest activity [α]D 25 45°. Cinchonine also gave optical activation but quinine and brucine did not. Phenylmalonanilic acid, was only obtained active in the form of its salt with cinchonidine. The kinetics of racemisation of phenylmalonamic acid are first order.Keywords
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