A 12-Year Prospective Study of Postinjury Multiple Organ Failure
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Open Access
- 1 May 2005
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 140 (5) , 432-440
- https://doi.org/10.1001/archsurg.140.5.432
Abstract
Multiple organ failure (MOF) remains a major source of postinjury morbidity and the leading cause of in-hospital mortality despite more than 25 years of intense investigation.1,2 The current pathophysiologic model of MOF focuses on uncontrolled systemic hyperinflammation as a unifying concept following a variety of insults.3-5 Thus, therapeutic strategies aimed at decreasing postinjury morbidity have targeted systemic hyperinflammation as a means to control associated organ dysfunction and progression to organ failure. Examples include damage control surgery, recognition of abdominal compartment syndrome, lung protective ventilation strategies, and tight glucose level control.6-9Keywords
This publication has 1 reference indexed in Scilit:
- Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress SyndromeNew England Journal of Medicine, 2000