Glomerular morphometry II: familial and nonfamilial haematuria

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Abstract
Differential glomerular cell counts and measurements of glomerular diameter were made in 13 children with Alport''s syndrome (AS), 4 with benign familial hematuria (BFH) and 15 with nonfamilial hematuria (NFH). Mesangial cellularity was increased in the 6 cases of NFH with diffuse mesangial deposits of IgA (IgA+). In AS, IgA+ and -NFH, epithelial cellularity decreased with age while glomerular diameter increased. In AS mesangial and endothelial cellularity also decreased with age. AS, IgA+ and -NFH evidently are 3 distinct entities. BFH, although similar in several respects to IgA-NFH, should be retained as a separate category due to its familial incidence of hematuria.