Regulation of lactate dehydrogenase activity: Reversible and isoenzyme-specific inhibition of the tetramerization process by peptides
- 1 March 1983
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 39 (3) , 281-282
- https://doi.org/10.1007/bf01955304
Abstract
The transition of inactive lactic dehydrogenase (LDH) subunits to functional tetramers is controlled by 2 naturally-occurring peptides. One of these peptides inhibits the folding/association/activation process of H-LDH and the other peptide, the reconstitution of M-LDH. NADH and NAD+ are isoenzyme-specific antagonists of the 2 inhibitory peptides.Keywords
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