Gonadal Function in Men with Testicular Germ Cell Cancer: The Influence of Cisplatin-Based Chemotherapy

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Abstract
Exocrine and endocrine gonadal function is abnormal in some of the testicular cancer patients who have been treated with orchidectomy alone and receive no cytotoxic treatment. A review of the literature reveals that cisplatin-based chemotherapy seems to induce additional long-term damage to spermatogenesis and Leydig cell function. Most patients regain active spermatogenesis after chemotherapy, whereas subclinical Leydig cell dysfunction persists. In order to elucidate whether the cisplatin-induced gonadal toxicity has clinical implications, observation periods exceeding those previously reported are required.

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