Effect of Intravenous Administration of Paritol-C on Serum Lipids of Hypercholesterolemic Rabbits.

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Abstract
Previous work had shown that rabbits fed a 0.5% cholesterol diet developed hypercholesterolemia, around 90% of the cholesterol being extractable from lyophilized serum by cold chloroform, whereas in normal rabbits only a small percentage of the total cholesterol could thus be extracted from the lyophilized serum. Intraven. injn. of 5-10 mg. of the heparinoid, Paritol-C, per pound of body weight into such hypercholesterolemic rabbits caused a marked drop in the various cholesterol fractions. The percentage drop in the fraction which is extracted by cold chloroform in a 3-hr. period[long dash]the "readily extractable" cholesterol[long dash]was usually greater than the drop in total cholesterol. The difference was especially pronounced when the total serum cholesterol had dropped to 700 mg. % or lower. The changes in the serum phospholipid and neutral fat content closely paralleled those of total cholesterol. Intraven. administration of Dicumarol had no effect on any of the fractions studied.

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