Sickle Cell Haemoglobin and two Types of Thalassaemia in the Same Family

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Abstract
Two heterozygote types of thalassemia were found in the same family: the classic type with erythrocytic alterations, elevated Hb A2 and normal Hb F and another type with more marked morphological alterations, normal Hb A2 and increased Hb F up to 9%. In the propositus and his sister classical thalassemia and Hb S were present simultaneously, giving a typical Hb S-thalas-semia disease. In the father. there was an association of Hb S and thalassemia with normal Hb A2 and increased Hb F. The result is the appearance of a moderate Hb S-thalassemia disease, in which Hb F is higher than in the heterozygotes, and Hb S is lower than 60%, but slightly higher than in sickle cell trait. Thalassemia with normal Hb A2 and increased Hb F is similar to [alpha] - and to [beta]-thalassemia, but the similarity to [beta]-thalassemia is much more evident.

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