Anticonvulsant Effect of Nialamide and Diphenylhydantoin.
- 1 December 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 108 (3) , 680-683
- https://doi.org/10.3181/00379727-108-27033
Abstract
Nialamide increased the maximal electroshock seizure threshold in mice and rats. This effect was independent of the elevation of brain 5-HT (hydroxytryptamine) and NE (norepinephrine) elicited by nialamide. Diphenylhydantoin in doses from 6 to 55 mg/kg, which was almost 9 times the anticonvulsive dose, did not significantly alter the content of 5-HT or NE in the brain of mice. Nialamide potentiated and reserpine decreased the anticonvulsant effect of diphenylhydantoin. No correlation could be found between these effects and brain amine levels.Keywords
This publication has 1 reference indexed in Scilit:
- Correlations Between Active Eyelid Closure and Depletion of Brain Biogenic Amines by Reserpine.Experimental Biology and Medicine, 1961