Diatrizoate Enemas: Facts and Fallacies of Colonic Toxicity

Abstract
Rats were given enemas of Gastrografin in 2 strengths, Renografin-76 and Tween-80 in a 10% dilution. There were no deleterious effects on colons with these media used in volumes to fill the colon. Severe changes resulted from volumes which produced overdistention.