Paracetamol, Tiaramide and Placebo for Pain Relief after Orthopedic Surgery

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Abstract
Patients [80] took part in this double-blind, single-dose group-comparative study comparing the analgesic efficacy of tiaramide hydrochloride 100 and 200 mg, paracetamol 1000 mg and placebo for pain after orthopedic operations. The 4 treatment groups were similar on entry to the trial. Pain relief was assessed up to 6 h after treatment, using a visual analog pain scale and a pain score, both giving similar results. Statistically significant pain relief (mean pain intensity differences and sum of pain intensity differences) was seen in the group receiving paracetamol compared to those receiving placebo or tiaramide from 1-6 h after drug ingestion. There was no significant difference between placebo and tiaramide 100 or 200 mg. No adverse reactions were reported.

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