Fluid partition and cardiac output in volume-depleted Goldblatt hypertensive rats

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Abstract
Cardiac output (CO) and fluid partition of extracellular fluid volume (ECFV) between the plasma volume (PV) and interstitial fluid volume (IFV) compartments were measured in conscious volume-depleted rats with 1 kidney Goldblatt hypertension (DG), depleted sham-operated (DS), normal-diet Goldblatt (NG) and normal-diet sham-operated (NS) rats 3 or 14 days after surgery. Mean arterial pressure increased significantly in DG and NG compared with their respective sham groups at both time periods despite decreased ECFV in DG. At 3 days, ECFV was significantly increased in NG, but not in DG compared to their respective sham groups. At 14 days ECFV was not significantly different between the hypertensive and normotensive rats. No evidence of a shift of IFV into PV was found in NG or DG at either time period. At 3 days, CO was 12% and total peripheral resistance (TPR) was 10% greater in DG and NG compared with DS and NS, respectively. At 14 days, only TPR was elevated (25% in NG and 48% in DG). Changes in CO and TPR in volume-depleted rats with 1-kidney Goldblatt hypertension evidently depend on factors other than ECFV expansion and translocation of fluid into the PV compartment.