Exercise and circulating hematopoietic progenitor cells (CFU‐GM) in humans

Publisher Website
Google Scholar
Abstract
In order to determine whether the rise in blood circulating committed hematopoeitic progenitor cells (CFU‐GM) was sustained long enough after exercise to be a practical adjunct to increasing stem cell yields by hemapheresis, the authors evaluated two exercise protocols in 15 normal donors. Immediately after a brief period of intense exercise, there was a significant increase in the absolute number of blood CFU‐GM from 164 +/− 27 to 240 +/− 46 per ml. However, all values returned to baseline within 15 minutes. Prolonging the exercise did not enhance either the circulating CFU‐GM concentration or the duration of the rise. If blood hematopoietic stem cells respond to exercise similarly, such a transient increase would not appear to be of use in stem cell harvesting.