Comparative Evaluation of Coloration of Photosensitive Solid Drugs under Various Light Sources

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Abstract
Photostability of 8 kinds of photosensitive solid drugs was evaluated from the point of coloration under various light sources, e.g., mercury vaporlamp, daylight lamp and 2 kinds of fluorescent lamps. Sample drugs examined were sulpyrine, chlorpromazine hydrochloride, perphenazine, indomethacin, promethazine hydrochloride, imipramine hydrochloride, furosemide and phenytoin. Coloration was determined by tristimulus colorimetry. To investigate the photosensitivity of these samples, their action spectra for coloration were obtained with a grating monochrometer in the range of irradiation wavelength 306-475 nm. Coloration process of each sample could be expressed as a straight line on a double-log scale. These processes changed corresponding to the combination of drug and light source, indicating different coloration reaction orders. The apparent orders and the degree of coloration were discussed in relation to the action spectrum of each sample. In some samples, the existence of photosensitive similarity in coloration between exaggerated and ordinary irradiation conditions was suggested.

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