Involvement of Double-Stranded RNA-Dependent Protein Kinase in ER Stress-Induced Retinal Neuron Damage

1 August 2007

journal article
Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science

Vol. 48 (8) , 3729-3736
https://doi.org/10.1167/iovs.06-1122

Abstract

Purpose. To clarify whether the activation of double-stranded RNA-dependent protein kinase (PKR) participates in the cell death induced by endoplasmic reticulum (ER) stress, the authors used cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with the E1A virus) in vitro and the effect of a PKR inhibitor (an imidazolo-oxindole derivative) on N-methyl-d-aspartate (NMDA)–induced retinal damage in mice in vivo.

Keywords

ER STRESS
ATF4
IMMUNOBLOTTING
NMDA
PKR
SIRNA
ENDOPLASMIC RETICULUM
GANGLION CELL
INDUCED RETINAL

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