Influence of temperature on the responses of the guinea-pig hypogastric nerve-vas deferens preparation

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Abstract
Over a temperature range of 32 to 20°, responses of the vas deferens to hypogastric stimulation at 50 shocks/sec became gradually smaller, while those to 10 shocks/sec increased gradually. A parallel study, under the same temperature conditions, of drugs known to interfere with peripheral sympathetic transmission revealed a marked reduction of the inhibitory properties of the adrenergic neurone blocking agents bretylium and xylocholine at the lower temperatures. The mechanism by which cooling modified the responses of the preparation to nerve stimulation as well as to the activity of the drugs on the vas is discussed and tentative hypotheses are advanced.