RS-61443 reverses acute renal allograft rejection in dogs
- 1 January 1992
- book chapter
- Published by Springer Nature
- Vol. 110 (4) , 542-543
- https://doi.org/10.1007/978-3-642-77423-2_159
Abstract
RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. At blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. At was possible to reverse this process.Keywords
This publication has 3 references indexed in Scilit:
- INHIBITION OF BOTH MLC AND IN VITRO IgG MEMORY RESPONSE TO TETANUS TOXOID BY RS-61443Transplantation, 1991
- Lymphocyte‐Selective Cytostatic and Immunosuppressive Effects of Mycophenolic Acid in Vitro: Role of Deoxyguanosine Nucleotide DepletionScandinavian Journal of Immunology, 1991
- RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENTTransplantation, 1991