A Comparison of the Side Effects and Antihypertensive Potency of Chlorothiazide and Hydrochlorothiazide

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Abstract
THE past decade has seen a dramatic change in the management of high blood pressure. A program consisting of sedatives, diets and surgery has gradually been replaced by one that is based on the use of antihypertensive medications, either singly or in various combinations. Although the great majority of subjects with hypertensive disease demonstrate a significant blood-pressure reduction and diminution or disappearance of certain symptoms when given these drugs1 2 3 many fail to respond satisfactorily. In such cases, when relatively small doses of the antihypertensive materials that were previously ineffective are supplemented with chlorothiazide, most "therapeutically refractory" cases can be managed . . .