High Performance Liquid Chromatography of Polychloro-2-(Chloromethyl Sulphonamido) Diphenyl Ethers and Their Impurities in the Mothproofing Agent, Eulan WA New, and in Water

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Abstract
The chromatography of the active ingredients of Eulan WA New (a mixture of chlorinated arylsulphonamides) and impurities (chloroanilides) is examined in the context of the three chromatographic processes applied in the extraction, cleanup, and analysis of these materials in natural water at the ng 1-1 level. The Eulan WA New is extracted from the water using DC-200 coated polyurethane foam plugs. This extraction is shown to be pH dependent. The plug extract is cleaned up on a layered acidic and basic alumina column and eluted with solvents of different polarities and acidities. The development of an HPLC method for Eulan WA New, and the effects of solvent composition, pH, column packing, and detector wavelength on the chromatography as well as the use of an internal standard are discussed.