Nutritional manipulations and tumor growth I. The effects of starvation

Open Access
Publisher Website
Google Scholar
Abstract
The effects of starvation on tumor and host growth were studied in growing male Fischer rats bearing methylcholanthrene-induced sarcomas. Tumor growth was evaluated by changes in weight, volume, and incorporation of tritiated methyl thymidine into tumor DNA, (dpm/µg DNA). Host growth was followed by changes in total body weight, carcass weight, and dpm/µg liver DNA. All periods of starvation (24 to96 hr) caused significant decreases in host body and carcass weight and dpm/µg liver DNA. Changes in tumor weight and tumor volume in fed and starved animals were equal. Tumor dpm/µg DNA in starved animals increased (P < 0.005) relative to fed controls at 48, 72, and 96 hr starvation intervals. Starvation allows continued tumor growth while host wasting occurs, and is accompanied by increased tumor dpm/µg DNA in this system.

This publication has 14 references indexed in Scilit: