Fate of naphthenic hydrocarbons in the bile of rainbow trout (Salmo gairdneri)

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Abstract
Rainbow trout (Salmo gairdneri) were exposed orally to n‐butylcyclohexane and on the sixth day after ingestion, 3 to 5% of the dose of parent compound was recovered as a metabolite in the bile. The glucuronide of cis‐3‐n‐butylcyclohexanol was identified as the single metabolic product. Exposure of trout to t‐butylcyclohexane afforded the glucuronide of 4‐t‐butylcyclohexanol in a much smaller amount. Comparative studies between these two small naphthenic hydrocarbons and the corresponding aromatic molecules are also reported.