THE MECHANISM OF THE CIRCULATORY CHANGES ACCOMPANYING INSULIN HYPOGLYCEMIA

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Abstract
Measurements of the heart rate, and of the min. vol. output of the heart according to the principle of Fick were made before and during insulin hypoglycemia in 3 groups of cats: (1) normal, (2) with denervated hearts, and (3) with denervated hearts and inactivated suprarenals. In group 2 (denervated hearts and intact suprarenals), insulin hypoglycemia was attended by an av. increase of 23% in the min. vol. output of the heart and an av. rise in heart rate of 34 beats per min. (26%). In contrast, in group 3 (denervated hearts and inactivated suprarenals), hypoglycemia caused an av. decrease of 10% in cardiac min. vol. output and an av. increase in heart rate of but 1 beat per minute (1%). These results indicate that both the increase in cardiac min. vol. output and the rise in ventricular rate during hypoglycemia in cats with denervated hearts and intact suprarenals result from an increased discharge of adrenin in response to stimulation of the sympathetic nerves to the suprarenal glands. The decrease in circulatory min. vol. observed during hypoglycemia in cats with denervated hearts and inactivated suprarenal glands indicates that hypoglycemia per se has a deleterious effect on the myocardium.

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