Results of an investigation of the therapeutic action of paludrine and pamaquin on acute attacks of benign tertian malaria

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Abstract
Summary 1. In a series of 179 cases treated with paludrine 250 mg., and pamaquin 10 mg. given concurrently 8 hourly for 10 days (Course P/X), the relapse rate was just over 20 per cent. The results of treatment of 168 cases with quinine 10 grains and pamaquin 10 mg. given concurrently 8 hourly for 10 days (Course QP) were almost identical. 2. The duration of temperature was appreciably shorter during Course QP than during Course P/X. 3. Toxic manifestations during Course QP were minimal and occurred in 7 per cent. of cases. During Course P/X, 37 per cent. of cases showed toxic manifestations which included cyanosis, anorexia and gastric discomfort. The clinical condition of patients during treatment with Course P/X compared unfavourably with the general good health of those on Course QP. 4. The dosage of 250 mg. of paludrine 8 hourly is considered too high to be given concurrently with 10 mg. of pamaquin, since equally successful treatment is attained with considerably lower doses which produce negligible toxic reactions.

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