Kanamycin

1 July 1959

journal article
research article
Published by American Medical Association (AMA) in Archives of internal medicine (1960)

Vol. 104 (1) , 15-28
https://doi.org/10.1001/archinte.1959.00270070017003

Abstract

Kanamycin was first described by Umezawa et al. in 1957¹; it is produced by Streptomyces kanamyceticus. Chemistry The crystalline sulfate of kanamycin is water-soluble, alcohol-insoluble, and basic. It is a very stable compound with less than 10% loss after autoclaving for one hour at 120 C; it is stable over a pH range of 2 to 11. Cron and his co-workers² have determined that kanamycin consists of two amino sugars linked glycosidally to 2-deoxystreptamine, with the structural formula shown in Figure 1. This structure resembles that of neomycin and has some similarity to streptomycin. Paper chromatography of kanamycin preparations reveals a second antibiotic, kanamycin B. Kanamycin B exhibited more toxicity than kanamycin A in animal studies ³ and is present to the extent of only 2% to 3% in later preparations of the drug. Microbiological Studies 1. Spectrum. —In vitro, kanamycin is active against a variety of

Keywords

ANTIBIOTICS

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