Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.
- 1 January 1987
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 43 (2) , 129-132
- https://doi.org/10.1254/jjp.43.129
Abstract
Hypertensive action was observed in conscious rats injected intraventricularly with glandular kallikrein (EC 3.4.21.35) in a dose-dependent manner (4-16 KU), which was associated with the enhancement of brain kinin level. Concurrently administered aprotinin, a kallikrein inhibitor, led to an inhibition of these effects of kallikrein. These results suggest that the central hypertensive action of kallikrein is mediated via the kinin liberated from a kininogen in the brain.This publication has 8 references indexed in Scilit:
- Central adrenergic mediation of the cardiovascular effect of intraventricular bradykininNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1986
- Regional Distribution and Characterization of Kinin in the CNS of the RatJournal of Neurochemistry, 1985
- Identification of Bradykinin in Mammalian BrainJournal of Neurochemistry, 1984
- The disappearance rate of intraventricular bradykinin in the brain of the conscious ratBiochemical and Biophysical Research Communications, 1982
- Relationship between central actions of bradykinin and prostaglandins in the conscious ratNeuropharmacology, 1982
- Effects of intraventricular injection of bradykinin on the EEG and the blood pressure in conscious ratsNeuropharmacology, 1981
- Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain.Proceedings of the National Academy of Sciences, 1979
- On the mechanism of the hypertensive action of intraseptal bradykinin in the ratNeuropharmacology, 1976