TREATMENT OF MYELOID BLASTIC CRISIS OF CHRONIC MYELOGENOUS LEUKEMIA

1 January 1984

journal article
research article

Vol. 68 (11) , 1351-1355

Abstract

Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy [cytoarabine, doxorubicin, prednisone, vincristine, busulfan] or by autologous hematpoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a 2nd chronic phase. Autologous transplantation resulted in the establishment of a 2nd chronic phase in 2 of 10 patients treated with a 4-drug regimen; treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a 2nd chronic phase in 3 of 6 patients and the return of normal hematopoiesis in a 4th. Consolidation chemotherapy appeared to be beneficial.

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