THE USE OF LABETALOL AS A MODERATE HYPOTENSIVE AGENT IN OTOLOGICAL OPERATIONS - PLASMA-CONCENTRATIONS AFTER INTRAVENOUS ADMINISTRATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (5) , 191-194
Abstract
The usefulness of labetalol, a combined .alpha. and .beta. adrenoceptor antagonist, as a moderate hypotensive agent during combination anesthesia in otological operations was studied. An i.v. dose of 2.0 mg/kg body wt of labetalol caused a moderate decrease in blood pressure without a concomitant increase in heart rate or excessive hypotension. The half-life of the elimination phase of labetalol in plasma varied between 3.9-6.3 h. A direct relationship between the i.v. dose of the drug (0.5, 1.0 and 2.0 mg/kg i.v.) and the increase in the AUC [area under the concentration time curve] value was observed. No correlation was found between the decrease in the systolic or diastolic blood pressure and the plasma level of labetlol. This new type of antagonist may have advantages over other current hypotensive drugs, i.e., lack of tachycardia and excessive hypotension.

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