IMAGING OF LYMPH-NODE UPTAKE AFTER INTRAVENOUS ADMINISTRATION OF IN-111 METALLOPORPHYRINS

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  • 1 February 1986
    • journal article
    • research article
    • Vol. 27  (2) , 239-242
Abstract
Indium-111-(111I) labeled tetra(N,N,N-trimethylanilinium)porphyrin (TTAP), tetra(N-methyl-4-pyridyl)porphrin (TMPyP), and tetra(4-sulfonatophenyl)porphyrin (T4SPP) were synthesized and lymph node uptake was measured in animals after intravenous administration. In rats (111IN] TTAP had maximum lymph node to muscle uptake ratios which averaged 85:1 between 24 and 48 hr postinjection. Total lymph node uptake was nearly 1% at that time. Lymph nodes in rabbits were clearly visualized by gamma scintigraphy at 48 hr after i.v. injection of labeled TTAP. These results suggest that 111In-labeled TTAP may be a prototype for the development of a class radiopharmaceuticals which permits visualization of lymph nodes after i.v. administration.