Effect of an opiate antagonist (naloxone) on the gastric acid secretory response to sham feeding, pentagastrin, and histamine in man
- 1 April 1982
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 27 (4) , 308-310
- https://doi.org/10.1007/bf01296749
Abstract
We studied the effect of the opiate antagonist naloxone on the human gastric acid secretory response to three secretory stimulants: sham feeding, pentagastrin, and histamine. Intravenous naloxone (40 μg/kg/hr) significantly inhibited the acid secretory response to sham feeding without affecting the serum gastrin response to sham feeding. Naloxone also significantly reduced pentagastrin- and histamine-stimulated acid secretion. These studies indicate that naloxone reduces acid secretion in response to all stimulants of acid secretion yet tested in humans.Keywords
This publication has 15 references indexed in Scilit:
- Down with multiple t-tests.1981
- Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humansGastroenterology, 1980
- Multiple opiate receptor sites on primary afferent fibresNature, 1980
- Studies on the role of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects.Journal of Clinical Investigation, 1977
- Endogenous opioid peptides: multiple agonists and receptorsNature, 1977
- ENKEPHALIN-LIKE IMMUNOREACTIVITY IN THE HUMAN GASTROINTESTINAL TRACTThe Lancet, 1977
- Drugs Five Years Later: NaloxoneAnnals of Internal Medicine, 1976
- KINETIC PARAMETERS OF NARCOTIC AGONISTS AND ANTAGONISTS, WITH PARTICULAR REFERENCE TO N‐ALLYLNOROXYMORPHONE (NALOXONE)British Journal of Pharmacology and Chemotherapy, 1968
- Effects of morphine, nalorphine, cyclazocine, and naloxone on the flexor reflexInternational Journal of Neuropharmacology, 1967
- HUMAN PHARMACOLOGY AND ABUSE POTENTIAL OF N-ALLYLNOROXYMORPHONE (NALOXONE)1967