Relationship Between Insulin Dosage, Duration and Degree of Hypoglycemia and Production of Brain Damage.

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Abstract
1. The larger the dose of insulin the greater the incidence of brain damage. However, irrespective of the insulin dose, brain damage did not occur in our animals unless they were kept in the “medullary stage” of hypoglycemia for at least 100 minutes. 2. In cats, not previously treated with insulin, the larger the dose the longer time it took for the appearance of neurologic signs of hypoglycemia.

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