CELLULAR SPECIFICITY OF NB70K, A PUTATIVE HUMAN OVARIAN TUMOR-ANTIGEN

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (2) , 864-867
Abstract
The cellular expression of NB/70K was studied. NB/70K is a glycoprotein proposed to be associated with human ovarian tumor. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells. Within such tumors, there is a weak inverse correlation between labeling index and antigen expression. Evidence is presented to show that the cells bearing this glycoprotein are physically separable from those bearing carcinoembryonic antigen.