Two New C22 1,2-Dioxane Polyketides from the Marine Sponge Acarnus cf. bergquistae

Abstract
Two new cyclic peroxide-containing polyketide C22 methyl esters, peroxyacarnoic acid methyl esters A and B, 1 and 2, have been isolated from the Red Sea marine sponge Acarnus cf. bergquistae. Both 1 and 2 are proposed to contain a single 1,2-dioxane ring, an eneyne functionality, and a terminal double bond or triple bond, respectively. The structures were elucidated mainly through 1D and 2D NMR spectral analysis.