The modification of guanine nucleosides and nucleotides by the borderline arylamine carcinogens 4-methyl- and 4-methoxyaniline: chemishy and structural characterization
- 1 September 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 12 (9) , 1633-1640
- https://doi.org/10.1093/carcin/12.9.1633
Abstract
We report here on the conformational analysis of C8-arylamine nucleoside and nucleotide adducts of the borderline carcinogen 4-methylaniline and 4-methoxyaniline. The non-phosphorylated adducts show anti conformation of the glycosidic link, while the corresponding 5′phosphorylated adducts have a syn conformation. All adducts exhibit a predominant C2′-endo conformation of the sugar ring and a gg conformation of the exocyctic bond.Keywords
This publication has 0 references indexed in Scilit: