Alteration Of The Chemical Composition Of Human Immunoglobulin G By Streptococcus Pyogenes

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Abstract
Incubation with Streptococcus pyogenes type 12 was shown to lead to marked alterations of the fucose, galactose, and total hexose content of human immunoglobulin G (IgG). Immunological studies showed at least partial identity of this altered IgG and normal IgG. Streptococcal antigen was not found in the altered immunoglobulin. We suggest that if such alterations occurred in vivo, the altered immunoglobulin might become autoimmunogenic or might possess the biological properties of immune complexes and thus be of immunopathological significance in post-streptococcal glomerulonephritis.

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