The effects of vasectomy on testicular metabolism in the guinea-pig

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Abstract
The effects of vasectomy on testicular DNA production were studied in guinea pigs at 2 wk and 2 and 6 mo. after surgery. By 6 mo., vasectomy resulted in lower testicular wt and absolute DNA, RNA and protein contents, although RNA and DNA concentrations/protein were unchanged. Incorporation of thymidine into the testis decreased by 2 wk after vasectomy, and continued to do so unless the ductal system subsequently ruptured and formed a granuloma when thymidine incorporation returned to normal control levels. In the guinea pig, vasectomy apparently alters spermatogenesis by reducing testicular DNA synthesis.

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