Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (1) , 340-344
- https://doi.org/10.1248/cpb.34.340
Abstract
A platelet activating factor (PAF) antagonist, designated as FR-49175, was isolated from fermentation products of Penicillium terlikowskii and identified as bisdethiobis(methylthio)gliotoxin (1). The IC50 value of this compound for PAF-induced rabbit platelet aggregation was 8.4 .mu.M. Some derivatives of bisdethiobis(methylthio)gliotoxin (1) were synthesized and their inhibitory activities on PAF-induced platelet aggregation were examined. Among these compounds, 5a,6-anhydrobisdethio-3,10a-bis(methylthio)gliotoxin (8) showed the most potent PAF inhibitory activity (IC50; 4.4 .mu.M).This publication has 0 references indexed in Scilit: