Essential fatty acids in the serum and cerebrospinal fluid of multiple sclerosis patients

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Abstract
Statistical evaluation of essential fatty acids (determined by gas chromatography) in the serum and CSF of patients with definite MS [multiple sclerosis] and acute CCT [craniocerebral trauma] showed marked differences as compared to healthy subjects. The decrease of essential fatty acids in MS patients differed from that of CCT patients. Whereas the fatty acid levels in the serum of MS patients revealed only minor differences as compared to the controls and CCT patients, MS patients did not show a clear decrease in the CSF, especially of linoleic and arachidonic acids. This difference was most pronounced in cholesterol esters in the CSF. One absorption study with safflower oil demonstrated normal enteral absorption of essential fatty acids and the ability to cross the blood-CSF barrier.