New designs and structure activity relationships in antitumoral aziridinyl cyclophospha(thia)zenes
- 19 December 1983
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 18 (1) , 337-340
- https://doi.org/10.1080/03086648308076034
Abstract
The partial aziridinolysis of (NPCl2)3,4 and (NPCl2)2 NSOCl yields non-geminal and geminal chloro-aziridinyl derivatives. Compounds N3P3Az6-nRn (R[dbnd]amino, alkoxy, aryloxy, id.) show in vitro and in vivo cytostatic activity. Structure-activity relationships are proposed. Phase I clinical trials of (NPAz2)2 NSOAz (Az[dbnd]1-aziridinyl) are summarized.Keywords
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