A REFRACTORY PERIOD FOLLOWING OESTROGENIC STIMULATION OF CELL DIVISION IN THE MOUSE UTERUS

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Abstract
SUMMARY: A single injection of oestradiol given to ovariectomized mice pretreated with progesterone for several days stimulates a large increase in cell division in the uterine stroma which reaches a maximum 24 hr. later. A second injection 48 hr. after the first, also stimulates stromal cell division, but a second injection 12–36 hr. after the first does not. This failure to respond is not due simply to depletion of the stock of cells ripe for division. Rather it appears that the uterus becomes insensitive to further stimulation for approximately 36 hr. Although a second injection 24 hr. after the first injection does not increase stromal cell division, it does lengthen the refractory period so that a third injection given at 48 hr. has no effect.

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