A new metabolite of butylated hydroxyanisole in man
- 1 October 1983
- journal article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 4 (4) , 389-396
- https://doi.org/10.1002/bdd.2510040410
Abstract
Butylated hydroxyanisole (I) is one of the most commonly used food antioxidants. Its use has been suggested to inhibit a variety of carcinogenic responses. The present study on the disposition kinetics of (I) in man indicates that contrary to previous reports, (I) undergoes significant O‐demethylation in the body yielding a tert‐butyl hydroquinone. It is suggested that this metabolic conversion may be responsible for some of the in vivo activities of (I) against chemical carcinogens.Keywords
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