Central β-Adrenergic Effects on the Control of Ventilation in Cats

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Abstract
.beta.-Adrenergic mimetics and blockers and a local anesthetic (xylocaine) were infused into the vertebral artery of paralyzed and artificially ventilated cats. Drug effects on the central control of ventilation was assessed by measuring the changes in phrenic nerve activity. .beta.-Mimetics [isoprenaline (1 and 2) Prenalterol (1)] made the phrenic nerve activity increase; .beta.-blockers [propranolol (1 and 2), metroprolol (1), oxprenolol (1 and 2)] decreased the phrenic nerve activity. .beta.2-Mimetics (Salbutamol) and blockers (Butoxamine, H 35/35 [.alpha.-4-dimethyl-N-isopropylphenylethanolamine]) had no clear effects. Mode of action of the .beta.-blockers apparently is not by their local anesthetic properties. Brain stem .beta.-adrenergic mechanisms stimulate the ventilatory control system. Receptors are apparently .beta.1 receptors.