3-Aryl-2-Unsubstituted Indoles through the Palladium-Catalysed Reaction of o-Ethynyltrifluoroacetanilide with Aryl Iodides
- 31 December 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 12 (12) , 1363-1366
- https://doi.org/10.1055/s-1997-1039
Abstract
The reaction of the readily available o-ethynyltrifluoroacetanilide with aryl iodides in the presence of catalytic amounts of Pd2dba3, an excess of K2CO3, in DMSO at 40 °C affords 2-unsubstituted-3-arylindoles in good yield. Subjection of o-ethynyltrifluoroacetanilide to the same reaction conditions in the absence of aryl iodides gives rise to the formation of indole in high yield.Keywords
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