ATTEMPTS TO IMPROVE IODIPAMIDE INTRAVENOUS CHOLANGIOGRAPHY

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Abstract
To improve intravenous cholangiography, efforts were made (a) to stimulate the liver pharmacologically in order to excrete more of the contrast medium, iodipamide, (b) to offer to the liver more iodipamide by attempting to block its renal excretion, (c) to cause the liver to excrete two cholangiographic agents, one oral and one intravenous, simultaneously, and (d) to determine if the state of body hydration can influence biliary excretion of iodipamide. None of these measures resulted in greater excretion of the contrast medium into the bile. With the administration of probenecid, dehydrocholic acid, and an oral cholangiographic agent, the biliary levels of iodipamide were actually depressed, probably because the two substances being handled simultaneously competed for a liver excretory mechanism.

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