REGENERATION OF CEREBRAL MICROVESSELS - MORPHOLOGIC AND HISTOCHEMICAL STUDY AFTER LOCAL FREEZE-INJURY

Google Scholar
  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (1) , 74-82
Abstract
The sequential changes that occur during regeneration of cerebral microvessels was studied in young mice after a local freeze-injury. The immediate breakdown in the blood-brain barrier to horseradish peroxidase was followed by dissolution of cells in the vessel wall although the basal lamina was preserved. The residual basal lamina formed the pathway for orderly regeneration of microvessels. At 3 days reactive endothelial cells with prominent pinocytosis and patent interendothelial channels were present at the edge of the lesion. By 5 days endothelialization of necrotic vessels was in progress with patent vascular channels and tight function formation. Establishment of astrocytic contacts or perivascular fibrosis by 7 days was generally followed by reconstitution of normal vascular morphology and integrity at 15-35 days after injury.