Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues
- 1 March 2003
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 370 (2) , 397-402
- https://doi.org/10.1042/bj20021853
Abstract
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.Keywords
This publication has 29 references indexed in Scilit:
- Selenium deficiency increases susceptibility to glutamate‐induced excitotoxicityThe FASEB Journal, 2002
- A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein PJournal of Biological Chemistry, 2002
- Mass Spectrometric Characterization of Full-length Rat Selenoprotein P and Three Isoforms Shortened at the C TerminusJournal of Biological Chemistry, 2002
- Selenoprotein P in Human Plasma as an Extracellular Phospholipid Hydroperoxide Glutathione PeroxidaseJournal of Biological Chemistry, 1999
- Equimolar Hg-Se Complex Binds to Selenoprotein PBiochemical and Biophysical Research Communications, 1997
- Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supplyFEBS Letters, 1996
- Toxicity, metabolism and absorption of selenite by isolated rat hepatocytesToxicology, 1995
- Selenoprotein P receptor from ratBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- Evidence for specific selenium target tissues and new biologically important selenoproteinsBiochimica et Biophysica Acta (BBA) - General Subjects, 1988
- A selenocysteine-containing selenium-transport protein in rat plasmaBiochimica et Biophysica Acta (BBA) - General Subjects, 1982