Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions
- 2 January 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 242 (2) , 387-390
- https://doi.org/10.1016/0014-5793(89)80507-1
Abstract
Sarafotoxin‐b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin‐b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin‐binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.Keywords
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