Apoprotein A-I and High Density Lipoprotein Subtractions in Patients with Chronic Renal Failure Receiving Hemodialysis

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Abstract
Serum concentration of apoprotein A-I (apo A-I) and cholesterol content in high density lipoprotein (HDL) subfractions were studied in 19 men and 11 women at the end stage of chronic renal failure undergoing hemodialysis. HDL2 cholesterol concentration was decreased in males [0.33 .+-. 0.12 (mean .+-. SD) mmol/l, controls 0.45 .+-. 0.09 mmol/l; P < 0.001]; in females HDL2 cholesterol was also decreased although without statistical significance (0.45 .+-. 0.15 vs. 0.55 .+-. 0.10 mmol/l). HDL3 cholesterol was significantly decreased in men (0.65 .+-. 0.11 vs. 0.77 .+-. 0.04 mmol/l; P < 0.001) and also in women (0.61 .+-. 0.12 vs. 0.82 .+-. 0.07 mmol/l; P < 0.005). Serum concentration of apo A-I was within the normal range (1.13 .+-. 0.16 g/l in males in 1.25 .+-. 0.17 g/l in females; controls 1.24 .+-. 0.17 and 1.35 .+-. 0.19 g/l, respectively). The raised apo A-I/HDL2 cholesterol ratio in both men and women suggests the existence of qualitative changes in HDL subfractions as proposed in previous studies measuring total apo A and total HDL cholesterol in patients with chronic renal failure receiving hemodialysis. These abnormalities in the relative composition of HDL subfractions could play an important role as a vascular risk factor in patients with chronic renal failure undergoing hemodialysis.