NEUTROPHIL MIGRATORY ACTIVITY IN SEVERE HEMORRHAGIC-SHOCK

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 10  (3) , 199-204
Abstract
Sepsis continues to be a major cause of patient death following hemorrhagic shock. To explain this increased susceptibility to infection on a cellular level, neutrophil function was studied in 9 adult baboons subjected to severe hemorrhage. Neutrophil migratory activity was significantly decreased immediately after hemorrhage (P < 0.05 vs. control) and continued to decline throughout the experiment. After an initial small decline, neutrophil adherence increased to significant levels after 4 h of hypotension (P < 0.05 vs. control). Apparently, increased susceptibility to infection after sustained hemorrhage is a result of impaired neutrophil function.