The effects of phenylpropanolamine and other sympathomimetics on food consumption and motor activity in mice

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Abstract
The effects of phenylpropanolamine on motor activity and on food intake were compared with those of S-amphetamine, ephedrine, 2-aminoindane and fenfluramine in groups of mice. Motor activity was additionally measured in mice pretreated with levodopa and benserazide, and food intake in mice pretreated with α-methyl-p-tyrosine. Amphetamine (2·5 mg kg−1) increased motor activity, phenylpropanolamine (10–40 mg kg−1) and 2-aminoindane (2·5–10 mg kg−1) decreased activity whilst ephedrine (2·5–40 mg kg−1) had a biphasic effect. Fenfluramine (10–40 mg kg−1) had negligible effect on activity. In mice pretreated with levodopa and benserazide both phenylpropanolamine and 2-aminoindane caused a massive increase in motor activity whilst fenfluramine’s action was not affected in the same way. Whilst the anorectic action of fenfluramine was considerably potentiated in mice pretreated with α-methyl-p-tyrosine, that of amphetamine, ephedrine, 2-aminoindane and phenylpropanolamine was either unaffected or initially antagonized. It is concluded that the mechanisms of motor and anorectic actions of phenylpropanolamine are similar to those of amphetamine.

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