The Treatment of Pinworm Infections in Humans (Enterobiasis) with Pyrvinium Chloride and Pyrvinium Pamoate

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Abstract
Summary A pinworm study employing pyrvinium chloride and pyrvinium pamoate is described. Differences in toxicity indicate the superiority of the pamoate over the chloride form, though both are equally efficacious in therapeutic value. The pamoate drug was shown to be more pleasant to the taste and caused no gastrointestinal disturbances. Employment of 2 mg/kg body weight divided tid for 7 consecutive days resulted in a 100% cure rate for both forms of the drug. Pyrvinium pamoate given in a single dose of 5 mg/kg effected a cure rate of 96%. All cure-rate data obtained were found to be statistically significant at the 1% level. The value of periodic “wormings” is discussed and its feasibility with the use of pyrvinium pamoate in a single dose regimen is indicated.