2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses

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Abstract
Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. Experiments using rats dosed by the oral route as a model system show that measurement of methaemoglobin content provides a very rapid and simple monitoring method, but is not very sensitive. Measurement of the ortho-hydroxy metabolites of the two compounds, as their benzoxazole derivatives, provides a much more sensitive, but complicated technique. Details of both methods are presented.